The PAN Foundation and Patient Advocate Foundation announced a strategic merger in March 2026. In the meantime, nothing is changing for patients. You can continue to apply for and use financial assistance from the PAN Foundation through panapply.org or by calling us at 1-866-316-7263. You can learn more about the announcement at uniting.patientadvocate.org.
Diagnosis codes
ICD-10: E83.39
About the disease
Hypophosphatasia (HPP) is a rare metabolic bone disease that affects the development, specifically the calcification or hardening, of bones and teeth, resulting in weakened bones and gum disease. Hypophosphatasia is also known as deficiency of alkaline phosphatase, or Rathbun disease. Subtypes include: perinatal, infantile, childhood (mild versus severe), adult, odontohypophosphatasia, pseudohypophosphatasia.
Source: National Institutes of Health
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